Keywords: Rheumatoid Arthritis, Brain Connectivity, Brain, fMRI (Resting State), Inflammation, Multimodal
Patients with the musculoskeletal disorder psoriatic arthritis improve their inflammation with current treatments but still experience pain. Previous neuroimaging findings have identified functional connectivity of the resting-state default mode network and we explored how such features associate with nociplastic pain using both agonistic and selective approaches. We observed increased connectivity between the default mode network and regions of the brain related to both increased pain intensity and decreased pain inhibition. The implications of such findings shift the focus onto targeting central pain pathways in people with psoriatic arthritis.
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