Abstract #0102

Muscle magnetization transfer ratio is promising biomarker of hereditary neuropathy with liability to pressure palsy

Alison R Roth¹, Ashley J Minks¹, Yongsheng Chen², Jun Li³, and Richard D Dortch¹

¹Barrow Neuroimaging Innovation Center, Barrow Neurological Institute, Phoenix, AZ, United States, ²Department of Neurology, Wayne State University School of Medicine, Detroit, MI, United States, ³Department of Neurology, Houston Methodist Hospital, Houston, TX, United States

Synopsis

Keywords: Muscle, CEST & MTMagnetization transfer ratio (MTR) and volume of thigh muscles were investigated as imaging biomarkers in Charcot-Marie-Tooth type 1A (CMT1A) and hereditary neuropathy with liability to pressure palsy (HNPP) patients. MTR was significantly different between HNPP and healthy control subjects; muscle volume was significantly different between CMT1A patients and healthy control subjects and HNPP patients. MTR and volume were found to be repeatable and reliable.

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