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Abstract #0119

Spherical Echo-Planar Time-resolved Imaging (sEPTI) for 3D highly-accelerated, distortion-free, time-resolved whole-brain T2* mapping

Nan Wang1, Yannick WE Brackenier1, Congyu Liao1, Siddharth Srinivasan Iyer1,2, Xiaozhi Cao1, Justin Haldar3, and Kawin Setsompop1,4
1Department of Radiology, Stanford University, Stanford, CA, United States, 2Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, 3Ming Hsieh Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, CA, United States, 4Department of Electrical Engineering, Stanford University, Stanford, CA, United States

Synopsis

Keywords: Data Acquisition, Data Acquisition, Echo-planar imaging, time-resolved imagingEPTI is a rapid time-resolved quantitative imaging method. In this work, we developed a spherical EPTI sampling trajectory (sEPTI) to improve its speed. To achieve fast imaging, sEPTI traverses a tight 3D spherical k-space using full ramp-sampling and variable echo-spacing, which also desirably increases its spatiotemporal incoherency. sEPTI was demonstrated in vivo to provide improved imaging performance over conventional block 3D-EPTI that requires 1.4x longer scan; achieving high-quality 1mm isotropic whole-brain proton-density and T2* maps in 48s. As part of this work, a novel and effective reconstruction approach to mitigate high-spatial-order ghosts in echo-planar acquisitions was also developed.

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