Abstract #0120

Ultrashort-echo time magnetization transfer (UTE-MT) for brain iron imaging

Humberto Monsivais¹, Gianna Nossa¹, Seokkyoon Hong², Taewoong Park², Fethi Sila Erdil¹, Xin Shen³, Antonia Susnjar², Ali Özen⁴, Serhat Ilbey⁴, Mark Chiew⁵, Jessica Huber⁶, Ulrike Dydak^1,7, and Uzay Emir^1,2

¹School of Health Sciences, Purdue University, West Lafayette, IN, United States, ²Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States, ³Radiology, University of California San Francisco, San Francisco, CA, United States, ⁴Department of Radiology, Medical Physics, University of Freiburg, Freiburg, Germany, ⁵Welcome Centre for Integrative Neuroimaging, University of Oxford, England, United Kingdom, ⁶Department of Audiology and Speech Sciences, Purdue University, West Lafayette, IN, United States, ⁷Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States

Synopsis

Keywords: Contrast Mechanisms, BrainWe have established a novel 3D dual-echo UTE-MT imaging method to assess hyperintense T1w signal in iron-rich brain areas by eliminating the ultra-short T2 constituents of the myelin signal via the magnetization transfer (MT) technique. Our preliminary results show improved positive image contrast in deep brain areas such as the substantia nigra (SN) and the LC. Other iron-rich areas in the basal ganglia (globus pallidus and putamen) also show improved contrast.

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