Abstract #0126
Magnetic Resonance Elastography reveals effects of immunotherapy on glioma biomechanics
Yannik Streibel1, Jessica Hunger1,2,3, Chenchen Pan4,5, Verena Turco2, Manuel Fischer1, Volker Sturm1, Kianush Karimian-Jazi1,4, Dennis A. Agardy2,3,5, Giacomo Annio6,7, Rami Mustapha8, Christopher B. Rodell9, Wolfgang Wick4,5, Ralph Sinkus6,7, Sabine Heiland1, Frank Winkler4,5, Michael Platten2,10, Martin Bendszus1, Michael O. Breckwoldt1,2, and Katharina Schregel1,4
1Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany, 2Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Consortium (DTK) within the German Cancer Research Center (DKFZ), Heidelberg, Germany, 3Faculty of Biosciences, Heidelberg University, Heidelberg, Germany, 4Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DTK) within the German Cancer Research Center (DKFZ), Heidelberg, Germany, 5Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany, 6INSERM UMRS1148 - Laboratory for Vascular Translational Science, University Paris, Paris, France, 7School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom, 8Richard Dimbleby Laboratory of Cancer Research, School of Cancer & Pharmaceutical Sciences, King’s College London, London, United Kingdom, 9School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, United States, 10Department of Neurology, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany
Synopsis
Keywords: Elastography, NeuroMRI and MRE were used to monitor the effects of immunotherapy on tumor volume, FA and biomechanics of murine orthotopic glioma. Treated tumors were significantly smaller, softer and had lower FA than controls. This difference was most pronounced when comparing tumor stiffness of both groups. Controls revealed heterogeneous tumor stiffness. We hypothesize that this is caused by viable tumor cells alternated with necrotic areas and presumably immune-suppressive iba1-positive cells. In contrast, biomechanical properties of treated animals correlated better with presence of macrophages/microglia and likely reflected anti-tumorigenic inflammation. Thus, MRE could prove useful for monitoring glioma response to therapy.
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