Abstract #0129

Multimodal serial assessment of neoadjuvant therapy response and recurrence-free survival in locally advanced breast cancer

Anum S. Kazerouni¹, Lanell M. Peterson¹, Isaac Jenkins², Alena Novakova¹, Hannah M. Linden¹, David Hockenbery¹, David Mankoff³, Jennifer Specht¹, and Savannah C. Partridge¹

¹University of Washington, Seattle, WA, United States, ²Fred Hutch Cancer Center, Seattle, WA, United States, ³University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: Breast, CancerWe investigated the combination of DCE-MRI and ¹⁸F-FDG PET for assessing metabolism/perfusion mismatch and predicting pathological response and recurrence-free survival (RFS) in women undergoing neoadjuvant chemotherapy (NAC) for breast cancer. Thirty-five patients with localized breast cancer were imaged with both modalities at 3 timepoints over the course of NAC. Greater mid-treatment decreases in imaging measures were predictive of pathological response and associated with improved long-term outcome. Furthermore, mid-treatment decreases in metabolism/perfusion ratios were predictive of RFS. These results indicate a complementary relationship between DCE-MRI and ¹⁸F-FDG PET metrics and potential value of metabolism/perfusion mismatch as a marker of response.

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