Keywords: Cancer, Treatment, DCE-MRI, DW-MRI, Therapy Response, Ktrans, ADCThirty patients with lower extremity soft tissue sarcoma were treated with preoperative chemoradiotherapy and underwent MRI exams including DCE- and DW-MRI pre-therapy, after the first cycle of therapy regimen, and after completion of therapy but before surgery. Ten patients had optimal and the other 20 had sub-optimal pathologic responses based on necrosis percentage of the surgical tumor specimens. Quantitative DCE-MRI markers and apparent diffusion coefficient (ADC) were superior to radiographic tumor size measurement in early prediction and evaluation of therapy response. Multi-parametric approach of combining DCE- and DW-MRI markers further improved early prediction of optimal vs. sub-optimal response.
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