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Abstract #0132

Self-supervised pretraining and network ensembling for spatial mapping of treatment-effect in recurrent GBM with physiologic MRI

Jacob Ellison1,2,3, Nate Tran1,2,3, Rany Hanna1,2, Julia Cluceru1,2, Joanna Phillips4,5, Annette Molinaro5, Valentina Pedoia1,2,3, Tracy Luks1, Anny Shai4,5, Devika Nair1, Javier Villanueva-Meyer1,2, Mitchel Berger5, Shawn Hervey-Jumper5, Manish Aghi5, Susan Chang5, and Janine Lupo1,2,3
1Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, 2Center for Intelligent Imaging, UCSF, San Francisco, CA, United States, 3Graduate Group in Bioengineering, UCSF - UC Berkeley, San Francisco, CA, United States, 4Pathology, UCSF, San Fransisco, CA, United States, 5Neurological Surgery, UCSF, San Francisco, CA, United States

Synopsis

Keywords: Machine Learning/Artificial Intelligence, ModellingPrior characterization of treatment-effect and tumor recurrence using deep learning approaches have not optimized for spatial classification within a single lesion, which could improve surgical planning and treatment. 10mm patches of pre-surgical anatomical and physiological images surrounding the locations of histopathologically-confirmed tissue samples were used to train our models. Including physiological images, pretraining on unlabeled data in an autoencoding task, and training with an alternative cross-validation approach that enabled many networks to be ensembled, we achieved an ensembled test AUROC of 0.814 and generated spatial maps of tumor probability and model uncertainty. Performance decreased when removing any of these components.

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Keywords