Keywords: Quantitative Imaging, Cancer, microstructure; diffusion; apoptosisReliable and sensitive methods for assessing the response of breast cancer to treatment are critical for timely adjustments of therapies for individual patients, and development of novel therapies. Different from the conventional tumor-volume-based criteria, we hypothesize that more specific microstructural information on the cellular level in tumors, such as changes in cell size, may provide more accurate characterization of therapeutic response. Using both in vitro cell experiments and in vivo xenograft experiments, we demonstrated that temporal changes in MR-derived cell sizes in triple-negative MDA-MB-231 tumors treated with either drug vehicle or paclitaxel provide a new means to assess treatment response.
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