Keywords: Muscle, Tumor, Soft-tissue sarcomas; Treatment assessment; RelaxometrySoft-tissue sarcomas is commonly treated by neoadjuvant radiation therapy followed by surgical resection. Current assessment of neoadjuvant therapy relies on pathological examinations after surgery. Nonetheless, noninvasive imaging assessment can be performed before and during the treatment, offering the opportunity for predicting and early assessing treatment response. This pilot study applied T2* mapping to evaluate neoadjuvant therapy in seven patients with soft-tissue sarcomas before, during the treatment, and before surgery. The results showed strong or moderate correlations between T2* measurements and percent necrosis from pathological examinations, suggesting the potential for using T2* mapping to predict and early assess treatment response.
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