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Abstract #0138

Detection and Assessment of Treatment Response in Multiple Myeloma using Whole-body DETECT: Quantitative Biomarkers of MRI and FDG-PET

Sheng Qing Lin1, Sebastian Fonseca1, Durga Udayakumar1,2, Alberto Diaz de Leon1, Orhan Oz1, Gurbakhash Kaur3, Aimaz Afrough3, Larry D. Anderson Jr.3, and Ananth J. Madhuranthakam1,2
1Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, 3Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States

Synopsis

Keywords: Cancer, Quantitative Imaging, Disease BiomarkersWBMRI-DETECT has been previously shown to have improved lesion conspicuity and shorter scan times compared to WBMRI-STIR and WBMRI-DWIBS in multiple myeloma. In this work, we demonstrate that quantitative biomarkers measured through WBMRI, fat fraction (FF) and apparent diffusion coefficient (ADC), have weak correlation suggesting both biomarkers to provide complementary information. Additionally, both ADC and FF showed negative correlation with the semiquantitative SUVmax from FDG-PET, demonstrating potential use of quantitative MRI biomarkers for the assessment of therapy response.

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Keywords