Meeting Banner
Abstract #0139

CEST Imaging of the APT and ssMT predict the overall survival of patients with glioma at the first follow-up after completion of radiotherapy at 3T

Nikolaus von Knebel Doeberitz1, Florian Kroh2,3, Johannes Breitling 4, Laila König5, Srdjan Maksimovic1, Svenja Grass1, Jürgen Debus5,6,7, Peter Bachert3,4, Heinz-Peter Schlemmer1,7, Mark E. Ladd3,4,7, Andreas Korzowski4, Steffen Goerke4, and Daniel Paech1,8
1Division of Radiology, German Cancer Research Center, Heidelberg, Germany, 2Divion of Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany, 3Department of Physics and Astronomy, University of Heidelberg, Heidelberg, Germany, 4Division of Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany, 5Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany, 6Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center, Heidelberg, Germany, 7Faculty of Medicine, University of Heidelberg, Heidelberg, Germany, 8Department of Neuroradiology, University Hospital Bonn, Bonn, Germany

Synopsis

Keywords: CEST & MT, Treatment, GliomaIn this prospective clinical study we compared the ability of asymmetry-based amide proton transfer-weighted (APTw) imaging with Lorentzian-fit-based (PeakAreaAPT and MTconst) and relaxation-compensated (MTRRexAPT and MTRRexMT) CEST-MRI of the amide proton transfer (APT) and semisolid magnetization transfer (ssMT) at 3T for the prediction of the overall survival of patients with glioma at the first follow-up after completion of radiotherapy. The APTw (HR=4.66, p<0.001) was more strongly associated with survival compared to the MTRRexAPT (HR=2.44, p=0.056) and MTconst (HR=2.54, p=0.044). The MTRRexMT and PeakAreaAPT did not display any association with survival.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Abstract Presentation Video

Keywords