Abstract #0140

Transmembrane water-efflux rate measured by water exchange DCE-MRI: a sensitive and specific biomarker of Aquaporin-4 in gliomas

Yinhang Jia^1,2, Guangxu Han¹, Zejun Wang¹, Yi-Cheng Hsu³, Yi Sun³, Bao Wang⁴, Yingchao Liu^5,6, and Ruiliang Bai^2,7

¹Key Laboratory of Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China, ²School of Medicine, Zhejiang University, Hangzhou, China, ³MR Collaboration, Siemens Healthcare, Shanghai, China, ⁴Department of Radiology, Qilu Hospital of Shandong University, Jinan, China, ⁵Department of Neurosurgery, Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, ⁶Shandong National Center for Applied Mathematics, Shandong University, Jinan, China, ⁷College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China

Synopsis

Keywords: Tumors, Brain, Glioma, Aquaporins-4, transmembrane water-efflux rate, therapy-resistant.

The water-selective channel aquaporin-4 (AQP4) contributes to the migration and proliferation of gliomas, and to their resistance to therapy. Here, we show, in glioma animal models, and in glioma patients, that transmembrane water-efflux rate is a sensitive and specific biomarker of AQP4 expression and can be measured via dynamic-contrast-enhanced magnetic resonance imaging. Water-efflux rates correlated with changes in the heterogeneity of intratumoural and intertumoural AQP4 in human gliomas and following treatment with the AQP4 inhibitor TGN020. Regions with low water-efflux rates contained higher fractions of stem-like slow-cycling cells and therapy-resistant cells, suggesting that maps of water-efflux rates could be used to identify gliomas that are resistant to therapies.

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