Abstract #0141

Non-invasive blood brain barrier integrity mapping in patients with high-grade glioma and metastasis by time-encoded arterial spin labelling

Gabriel Hoffmann^1,2, Christine Preibisch^1,2, Matthias Günther^3,4,5, Amnah Mahroo³, Matthias JP van Osch^6,7, Lena Václavů⁶, Lena Schmitzer¹, Claus Zimmer^1,2, Benedikt Wiestler¹, and Stephan Kaczmarz^1,2,8

¹Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany, ²TUM-Neuroimaging Center, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany, ³MR Physics, Fraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany, ⁴MR-Imaging and Spectroscopy, University of Bremen, Bremen, Germany, ⁵mediri GmbH, Heidelberg, Germany, ⁶C.J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁷Leiden Institute of Brain and Cognition, Leiden University, Leiden, Netherlands, ⁸Philips GmbH Market DACH, Hamburg, Germany

Synopsis

Keywords: Tumors, Permeability, Blood Brain Barrier

High-grade glioma are known to cause blood brain barrier (BBB) disruption, facilitating molecular leakage from inside the vessels into tissue. Current methods to probe BBB integrity are either not quantitative or, by using Gadolinium, insensitive to subtle changes. Here, we present first data of arterial spin labelling (ASL)-based BBB mapping of water exchange time (Texch) in brain tumour patients. Results show faster exchange (shorter Texch) in tumorous and even normal-appearing tissue compared to healthy subjects. This highlights the potential of ASL-based water exchange mapping as a proxy measure for BBB integrity, and its potential sensitivity to even subtle impairments.

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