Abstract #0142

Imaging metabolism of deuterated glucose in patients with primary brain tumors

Zachary A. Corbin¹, Yanning Liu², Robert K. Fulbright³, Serena Thaw-Poon¹, Joachim M. Baehring¹, Nicholas Blondin¹, Peter Kim¹, Antonio Omuro¹, Veronica L. Chiang⁴, Jennifer Moliterno⁴, Sacit B. Omay⁴, Joseph M. Piepmeier⁴, Douglas L. Rothman³, Robin A. de Graaf³, and Henk M. De Feyter³

¹Department of Neurology, Yale University, New Haven, CT, United States, ²Department of Biomedical Engineering, Yale University, New Haven, CT, United States, ³Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, ⁴Department of Neurosurgery, Yale University, New Haven, CT, United States

Synopsis

Keywords: Tumors, Metabolism, deuteriumDeuterium metabolic imaging (DMI), a combination of ²H MRSI with administration of a deuterated substrate, was used to map regional metabolism of [6,6’-²H₂]-glucose in 24 patients with multiple types of brain tumors. DMI data were acquired 70-90 minutes after oral intake of the deuterated glucose and revealed strong tumor-to-brain image contrast in high-grade tumors. Our metric, based on the labeling of specific glucose metabolites, reflects the canonical glucose metabolism in aggressive tumors – the Warburg Effect. The Warburg Effect appears higher in high-grade tumors and showed potential as a biomarker of treatment effect.

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