Abstract #0143

Probing Tumor Heterogeneity in Mouse Glioblastoma with Dynamic Glucose-Enhanced Deuterium Metabolic Imaging

Rui Vasco Simoes^1,2, Rafael N Henriques¹, Jonas L Olesen^3,4, Beatriz M Cardoso¹, Francisca F Fernandes¹, Tania Carvalho¹, Sune N Jespersen^3,4, and Noam Shemesh¹

¹Champalimaud Research, Champalimaud Foundation, Lisbon, Portugal, ²(Present Address) Preclinical MRI, Institute for Research & Innovation in Health (i3S), Porto, Portugal, ³Center of Functionally Integrative Neuroscience (CFIN) and MINDLab, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, ⁴Department of Physics and Astronomy, Aarhus University, Aarhus, Denmark

Synopsis

Keywords: Tumors, Deuterium, gliomaDynamic glucose-enhanced deuterium MRS (DGE ²H-MRS) coupled with Marchenko-Pastur PCA (MPPCA) denoising has been recently applied to immunocompetent mouse glioblastoma subtypes (GL261 and CT2A), demonstrating the ability to measure glucose metabolism through glycolysis and mitochondrial oxidation non-invasively, and its association with tumor proliferation. Here, we extend this approach to DGE Deuterium Metabolic Imaging (DGE-DMI) coupled with tensor MPPCA (tMPPCA) denoising, to map glucose fluxes in the same mouse models of glioblastoma. Our results demonstrate a strong association between glycolytic rates and MRI and histologic features of inter/intra-tumor heterogeneity.

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