Abstract #0144

An exploration of peritumoral glutamate and glutamine in diffuse gliomas using 7T MRSI

Gilbert Hangel^1,2,3, Philipp Lazen^1,2, Sukrit Sharma², Cornelius Cadrien^1,2, Thomas Roetzer-Pejrimovsky⁴, Eva Niess², Lukas Hingerl², Stephan Gruber², Bernhard Strasser², Barbara Kiesel¹, Adelheid Woehrer⁴, Matthias Preusser⁵, Julia Furtner^6,7, Wolfgang Bogner², Siegfried Trattnig², Karl Rössler¹, and Georg Widhalm¹

¹Department of Neurosurgery, Medical University of Vienna, Vienna, Austria, ²High-field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ³Christian Doppler Laboratory for MR Imaging Biomarkers, Vienna, Austria, ⁴Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, Vienna, Austria, ⁵Division of Oncology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria, ⁶Division of Neuroradiology and Musculoskeletal Radiology, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ⁷Medical Image Analysis und AI, Danube Private University, Krems, Austria

Synopsis

Keywords: Tumors, Spectroscopy

Research indicates that glutamate (Glu) and glutamine (Gln) play a role in the infiltrative properties of diffuse gliomas. Overcoming limitations of previous MRSI techniques, our 7T MRSI approach allows high-resolution Glu imaging. We investigated intra- and peritumoral Glu and Gln in a cohort of 36 patients and found significant increases in peritumoral Glu/tNAA, Gln/tNAA, Glu/tCr, and Gln/tCr compared to a NAWM control region. We established peritumoral Dice similarity coefficients of 0.67 for Glu/tNAA and Gln/tNAA compared to 0.31 for tCho/tNAA.

Our results that Glu/Gln imaging could investigate the metabolism of infiltrative gliomas.

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