Keywords: Tumors, Brain, Glioblastoma, GBM, TERT, GABP, imaging, MRI, MRS, NMRTERT promoter mutation is a genetic hallmark of glioblastoma, and targeting TERT or its upstream transcriptional factor GABPB1 are considered ideal therapeutic targets. Accordingly, establishing reliable imaging modalities that will enable monitoring of TERT silencing are needed as early indicators of target engagement and response to these molecular targeting therapies. Here, we demonstrate that using 13C MRS to monitor the metabolism of hyperpolarized δ-[1-13C] gluconolactone via the pentose phosphate pathway to 6-phosopho-[1-13C]gluconate (6PG) provides such a noninvasive imaging readout of TERT or GABPB1 silencing in glioblastoma.
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