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Abstract #0146

AMIDE PROTON TRANSFER IMAGING-ARTERIAL SPIN LABELING MISMATCH – A NEW IMAGING BIOMARKER FOR PILOCYTIC ASTROCYTOMA

Adhithyan Rajendran1, Chidambaranathan Natesan2, Lavanya Yegnaraman2, Rakesh Jalali3, Rashmi Rao4, Manikandan Mariyapillai5, Prashant Jawahar1, Roopesh Kumar6, Srinivas Chilukuri7, and Sushma Patil8
1Radiology, Apollo Proton Cancer Centre, Chennai, India, 2Radiology, Apollo Hospitals Greams Road, Chennai, India, 3Radiation Oncology, Apollo Proton Cancer Centre, chennai, India, 4Radiology, Philips India Ltd, Bangalore, India, 5Philips India Ltd, Chennai, India, 6Neurosurgery, Apollo Proton Cancer Centre, Chennai, India, 7Radiation Oncology, Apollo Proton Cancer Centre, Chennai, India, 8Pathology, Apollo Proton Cancer Centre, Chennai, India

Synopsis

Keywords: Tumors, CEST & MT, Amide Proton Transfer ImagingAtypical features of Pilocytic astrocytoma (PA) on conventional MR imaging are often challenging and can be mistaken as High-grade glioma. Advanced Novel techniques of Amide Proton Transfer (APT) and Arterial spin labelling (ASL) have shown promising results in the grading of gliomas. This study to explore the added value and utility in characterizing the atypical form of PA, if these two non-contrast techniques are combined in the clinical practice. Mismatch between APT and ASL signals, was seen in all the cases of PA and this unique imaging appearance of APT ASL imaging mismatch could be a biomarker for pilocytic astrocytoma.

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