Abstract #0147

Tumor Blood Volume Measurement in Brain Gliomas Using Velocity-Selective Arterial Spin Labeling

Yaoming Qu¹, Qin Qin^2,3, and Zhibo Wen¹

¹Radiology, Zhujiang Hospital of Southern Medical University, Guangzhou, China, ²The Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA, Baltimore, MD, United States

Synopsis

Keywords: Tumors, PerfusionVelocity selective arterial spin labeling (VSASL) has shown comparable CBF measurements in brain gliomas with DSC-PWI. As CBV derived from DSC-PWI is the most widely adopted perfusion marker of brain tumor angiogenesis, the clinical utility for neurooncology imaging of VSASL based CBV quantification worth investigation. This study on preoperative patients with brain gliomas demonstrated that VSASL provided highly correlated quantifications of relative tumor blood volume (R²=0.83) compared to DSC-PWI, and further improved diagnostic performance than VSASL derived relative tumor blood flow measurements (ROC AUC=0.94 vs. 0.89), indicating its potential as a viable non-contrast alternative to DSC-PWI for brain tumor applications.

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