Abstract #0150

Tumour virtual histology with Magnetic Resonance Elastography

Giacomo Annio^1,2, Robin Bugge³, Siri Fløgstad Svensson ³, Omar Darwish⁴, Giorgio Seano⁵, Donata Biernat ⁶, Karoline Skogen ⁶, Jon Ramm-Pettersen ⁷, Einar Vik-Mo ⁷, Katharina Schregel ⁸, Kyrre Eeg Emblem³, and Ralph Sinkus¹

¹INSERM - King's College, Paris, France, ²School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ³Department of Diagnostic Physics, Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway, ⁴Department of Biomedical Engineering, King's College London, London, United Kingdom, ⁵U1021 INSERM, Institut Curie, Paris, France, ⁶Department of Radiology Ullevål, Division of Radiology and Nuclear Medicine,, Oslo University Hospital, Oslo, Norway, ⁷Department of Neurosurgery, Division of Clinical Neuroscience,, Oslo University Hospital, Oslo, Norway, ⁸Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany

Synopsis

Keywords: Tumors, ElastographyThe reciprocal interaction between cancer cells and the surrounding creates a tumorigenic feedback loop capable of shifting the anti-neoplastic feature of the microenvironment towards a tumour growth-promoting one. Unfortunately infiltrating tumours, like GBMs, do not have discrete boundaries and intra-axial metastases are not visible on conventional MR images. However they are expected to change the tissue biomechanics. Here we explored tumour microenvironment biomechanics non-invasively using MRE in a cohort of 23 patients with brain tumours - 13 meningiomas, 10 glioblastomas. We show how MRE provides a comprehensive characterization of the tumour microenvironment, explaining histological features and tumour invasive features.

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