Abstract #0151

Repeatability and reproducibility of a multi-vendor spin and gradient echo (SAGE) pulse sequence for dynamic susceptibility contrast MRI

Poonam Choudhary¹, YuXiang Zhou², Sudarshan Ragunathan³, Ethan Mathew¹, Aliya Anil¹, Natenael Semmineh⁴, Belinda Gutierrez¹, John P Karis⁵, Leland S. Hu², Kathleen M. Schmainda⁶, Ashley M. Stokes¹, and C. Chad Quarles⁴

¹Division of Neuroimaging Research and Barrow Neuroimaging Innovation Center, Barrow Neurological Institute, Phoenix, AZ, United States, ²Department of Radiology, Mayo Clinic College of Medicine, Phoenix, AZ, United States, ³Hyperfine Inc., Guilford, CT, United States, ⁴The University of Texas MD Anderson Cancer Center, Houston, TX, United States, ⁵Neuroradiology, Southwest Neuroimaging at Barrow Neurological Institute, Phoenix, AZ, United States, ⁶Department of Biophysics Medical College of Wisconsin, Milwaukee, WI, United States

Synopsis

Keywords: Tumors, DSC & DCE Perfusion, sequenceSingle-echo pulse sequences are commonly employed for DSC-MRI. The multi-echo spin and gradient echo (SAGE) sequence can be useful in multi-contrast and multi-scale imaging of morphologic and functional features of brain tumor vasculature. The goal of this study is to establish harmonized SAGE sequence and analysis protocol across primary MRI vendors to facilitate multi-site clinical trials. In this work, we present initial results of SAGE sequence multi-site reproducibility and repeatability in phantom, healthy volunteers and high-grade glioma patients.

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