Abstract #0152

Diffusion tensor imaging on a 1.5T MR-Linac and comparison to a 3T diagnostic scanner in glioma patients

Liam S. P. Lawrence¹, Rachel W. Chan¹, James Stewart², Mark Ruschin², Aimee Theriault², Sten Myrehaug², Jay Detsky², Pejman J. Maralani³, Chia-Lin Tseng², Hany Soliman², Mary Jane Lim-Fat⁴, Sunit Das⁵, Greg J. Stanisz^1,6, Arjun Sahgal², and Angus Z. Lau¹

¹Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ²Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ³Medical Imaging, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁴Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁵Department of Surgery, St. Michael's Hospital, Toronto, ON, Canada, ⁶Department of Neurosurgery and Paediatric Neurosurgery, Medical University, Lublin, Poland

Synopsis

Keywords: Tumors, Diffusion Tensor ImagingDiffusion tensor imaging was implemented on a 1.5T MR-Linac and used to scan ten glioma patients and four healthy volunteers. Mean diffusivity and fractional anisotropy (FA) measurements were compared to those at 3T in 35 glioma patients. FA values surrounding the tumour and in white matter structures (genu, splenium, and body of corpus callosum) were investigated for the detection of tumour infiltration and radiation-induced damage, respectively. There was no evidence of dose-dependent white matter changes, in contrast to previous literature. Peritumoural FA changes occurred more frequently for high-grade compared to low-grade gliomas.

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