Abstract #0169

Cardiac adipose tissue proton-density fat fraction quantification by free-running cardiac Dixon at 3T

Pierre Daudé^1,2, Thomas Troalen³, Adèle L C Mackowiak^4,5,6, Emilien Royer^1,2, Davide Piccini^4,7, Jérôme Yerly^4,8, Josef Pfeuffer⁹, Frank Kober^1,2, Sylviane Confort Gouny^1,2, Monique Bernard^1,2, Matthias Stuber^4,8, Jessica A M Bastiaansen^5,6, and Stanislas Rapacchi^1,2

¹Aix-Marseille Univ, CNRS, CRMBM, Marseille, France, ²APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, ³Siemens Healthcare SAS, Saint-Denis, France, ⁴Department of Diagnostic and Interventional Radiology, Lausanne University Hospital, Lausanne, Switzerland, ⁵Department of Diagnostic, Interventional and Pediatric Radiology (DIPR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland, ⁶Translation Imaging Center (TIC), Swiss Institute for Tranlational and Entrepreneurial Medicine, Bern, Switzerland, ⁷Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland, ⁸Center for Biomedical Imaging, Lausanne, Switzerland, ⁹Siemens Healthcare, MR Application Development, Erlangen, Germany

Synopsis

Keywords: Fat, Quantitative ImagingFree-running cardiac Dixon-MRI has the potential for motion-resolved R₂* and PDFF quantification to explore cardiac fat accumulation and alteration in metabolic diseases. This study combines a self-navigated 3D radial sequence with 13 echoes using fast bipolar signal-readouts, a k-space trajectory correction, a compressed sensing reconstruction, and IDEAL fat-water separation to obtain precise ( limits of agreement: ±1.2 % and 5.0 s^-1) and highly spatially and motion-resolved quantitative PDFF and R₂* maps of the whole heart. We report here the first in vivo characterization of metabolically-active epicardial fat (PDFF: 81.6±9.6 %), distinct from adjacent paracardial fat.

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