Abstract #0170

Evaluation of Cardiac Microstructure in Patients with Severe Aortic Stenosis Using Diffusion Tensor MRI with Submillimeter Resolution

Christopher A. Rock^1,2, Iris Y. Chen², Anne L. Philip¹, Boris Keil^2,3, Christopher T. Nguyen^2,4,5, and David E. Sosnovik ^1,2,5

¹Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States, ²A.A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ³Institute of Medical Physics and Radiation Protection, TH Mittelhessen University of Applied Sciences, Giessen, Germany, ⁴Cardiovascular Innovation Research Center, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, OH, United States, ⁵Health Sciences and Technology Program, Harvard - Massachusetts Institute of Technology, Cambridge, MA, United States

Synopsis

Keywords: Myocardium, Diffusion Tensor ImagingThis study describes a method to acquire submillimeter resolution diffusion tensor MRI scans of the human heart in vivo. Imaging was performed in healthy controls and patients with severe high flow-high gradient aortic stenosis. The images were processed to generate helix angle maps of cardiomyocyte orientation and compared. The range of helix angles across the myocardium was higher in subjects with aortic stenosis and the relative helix angle slope was also increased in patients with aortic stenosis.

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