Abstract #0171

In-Vivo CEST MRI to assess and identify myocardial infarction by using natural D- glucose as a contrast agent

Ajay Peddi¹, Daniel Schache¹, Ali Nahardani², Michael Kuhlmann³, Moritz Wildgruber^1,4, Cornelius Faber¹, and Verena Hoerr^1,2

¹Translational Research Imaging Center, Clinic of Radiology, University of Münster, Münster, Germany, ²Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, Bonn, Germany, ³European Institute for Molecular Imaging, University of Münster, Münster, Germany, ⁴Clinic and Polyclinic for Radiology, University Hospital of München, München, Germany

Synopsis

Keywords: Myocardium, CEST & MTThe current preclinical study aimed to explore the application of natural D-glucose as an infusible biodegradable MRI contrast agent for imaging of myocardial infarction (MI) by glucose weighted CEST MRI (glucoCEST). To this end, in a mouse model of MI, the infarct region was first identified and verified by late gadolinium enhancement MRI and histology, respectively. In-Vivo glucoCEST MTRasym maps showed substantial differences before and after glucose infusion according to the myocardial viability. Statistical analysis verified that glucoCEST contrast could distinguish significantly between MI region, remote myocardium as well as healthy myocardium.

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