Abstract #0175

Myocardial oxygen extraction fraction moderately correlates with fibrosis burden in patients after heart transplant: a MR metabolism study

Jing Wang¹, Ran Li², Xiaona Fu³, Yang Yang⁴, Xiaojie Sun³, Shenglei Shu³, Jie Zhao³, Xiangchuang Kong³, and Jie Zheng²

¹Radiology, Union hospital, Wuhan, China, ²Mallinckrodt Institute of Radiology, Washington University in St Louis, St. Louis, MO, United States, ³Union hospital, Wuhan, China, ⁴Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States

Synopsis

Keywords: Myocardium, Transplantation, oxygen metabolismMicrovascular dysfunction and excessive fibrous burden are independent prognostic factors after heart transplantation. A new novel cardiovascular MR technique for the measurement of myocardial oxygen extraction fraction was evaluated for a feasibility study in 10 patients after heart transplantation. It was observed that oxygen extraction fraction was significantly correlated with myocardial extracellular volume (diffuse fibrosis indicator). Further research with more patients is warranted to explore this new CMR metabolism index for early diagnosis of cardiac dysfunction in these patient cohorts.

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