Abstract #0176

Non-invasive magnetic resonance imaging agent for in-vivo nitric oxide activity detection

Anlan Hong^1,2, Kyle D. W. Vollett^1,2, Aaron M. Troy^1,2, and Hai-Ling Margaret Cheng^1,2,3

¹Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada, ²Translational Biology & Engineering Program, Ted Rogers Centre for Heart Research, Toronto, ON, Canada, ³The Edwards S. Rogers Sr. Department of Electrical & Computer Engineering, University of Toronto, Toronto, ON, Canada

Synopsis

Keywords: Inflammation, Preclinical

We report a novel nitric oxide (NO)-sensitive MRI contrast agent that holds potential for detecting endogenous NO. Type I collagen and HEK cell lysate showed strong binding with NO agent, while HSA and various ROS/RNS species showed NO agent was only activated by NO. In vivo washout rate was also tested, and NO agent cleared from mice 7 days after intraperitoneal injection. Prolonged enhancement was observed in the heart after isoproterenol injection, which indicated excess NO production and inflammation. The NO agent shows promise as a molecular imaging agent in early detection of inflammatory diseases.

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