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Abstract #0177

Quantification of abnormal metabolism in hypertrophic cardiomyopathy patients using hyperpolarized [1-13C]-pyruvate MRI

Avantika Sinha1, Xiaoxi Liu1, Shuyu Tang1,2,3, Nicholas Dwork1,4, Sanjay Sivalokanathan5, Jing Liu1, Robert Bok1, Karen G Ordovas6, James Slater1, Jeremy W Gordon1, M Roselle Abraham7, and Peder Eric Zufall Larson1,2
1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, Berkeley, San Francisco, CA, United States, 3HeartVista, Palo Alto, CA, United States, 4Departments of Bioinformatics and Radiology, University of Colorado School of Medicine, Aurora, CO, United States, 5University of Pennsylvania, Philadelphia, PA, United States, 6University of Washington, Seattle, WA, United States, 7Department of Medicine –Cardiology Division, University of California, San Francisco, San Francisco, CA, United States

Synopsis

Keywords: Myocardium, CardiomyopathyHypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy with a worldwide prevalence of ~1:250. It is the leading cause of sudden cardiac death often during exercise and in otherwise healthy, young individuals. We applied hyperpolarized [1-13C]-pyruvate MRI for metabolic imaging to 3 patients with HCM using multi-slice, dynamic metabolite-specific imaging with autonomous scanning. We observed focal metabolic abnormalities corresponding to regions of hypertrophy in patients with asymmetric non-obstructive HCM and differences in metabolism measurements compared to healthy volunteers.

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Abstract Presentation Video

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