Abstract #0182

Quantitative Perfusion with Rate-Pressure Product Corrections in Heart Transplant Patients with Cardiac Allograft Vasculopathy

Jay Bharatsingh Bisen¹, Sandra Quinn¹, Ozden Kilinc¹, Havisha Pedamallu¹, Kelvin Chow^2,3, Rachel Davids^2,3, Daniel C Lee⁴, Daniel Kim¹, Richard L Weinberg⁴, James Carr¹, Michael Markl¹, Bradley D Allen¹, and Ryan Avery¹

¹Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States, ²Radiology, Northwestern University, Chicago, IL, United States, ³Siemens Healthcare, Chicago, IL, United States, ⁴Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States

Synopsis

Keywords: Vessels, Quantitative Imaging, Quantitative Perfusion, Heart Transplant, Coronary Allograph VasculopathyCardiac Allograft Vasculopathy (CAV) is a form of accelerated intimal hyperplasia in heart transplant patients that limits long-term survival. Quantitative perfusion is a novel MR imaging technique that is useful in determining myocardial blood flow (MBF) and myocardial perfusion reserve (MPR) in CAV patients. After Rate-Pressure Product MBF corrections, Quantitative perfusion has shown that vessels with severe CAV (>70% stenosis) have significantly decreased MPR driven primarily by increased resting MBF. Quantitative perfusion may improve non-invasive monitoring of CAV status in heart transplant patients.

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