Abstract #0188

In vivo CEST-Dixon MRI in axillary lymph nodes with and without carcinoma: potential for noninvasive determination of lymph node metastasis

Rachelle Crescenzi^1,2, Paula M.C. Donahue^3,4, R. Sky Jones⁵, Chelsea Lee⁶, Maria Garza^1,5, Niral J Patel⁶, Ingrid Meszoely⁷, and Manus J Donahue^5,8

¹Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ²Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ³Physical Medicine and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, United States, ⁴Dayani Center for Health and Wellness, Vanderbilt University Medical Center, Nashville, TN, United States, ⁵Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, ⁶Division of Pediatric Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, ⁷Department of Surgical Oncology, Vanderbilt University Medical Center, Nashville, TN, United States, ⁸Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, United States

Synopsis

Keywords: Breast, CEST & MT, cancer, lymph node, metastasis, breast cancerThe overall goal of this work is to apply a CEST-Dixon MRI approach in the axillary lymph nodes (LNs) of women with breast cancer to test fundamental hypotheses about biochemical LN profiles with carcinoma. Mean z-spectra and corresponding significant differences in cohorts with metastatic vs. benign LNs were observed in regions of known chemical exchange for the nuclear Overhauser effect (PTR=0.087 vs. 0.051, p=0.04), hydroxyl (PTR=0.272 vs. 0.212, p=0.003), and amine (PTR=0.081 vs. 0.033, p=0.003) protons. CEST-Dixon MRI of LNs may have relevance for pre-surgical breast cancer staging and for guiding LN sparing resections to reduce risk for lymphedema.

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