Abstract #0222

Multi-Echo EPI Increases Sensitivity to BOLD Activation in the Olfactory Network Compared to Single-Echo EPI

Sichen Ludwig Zhao^1,2, Clara U Raithel^2,3, Jay A Gottfried^2,3, John A Detre², and M Dylan Tisdall⁴

¹Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, United States, ²Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, ³Department of Psychology, School of Arts and Science, University of Pennsylvania, Philadelphia, PA, United States, ⁴Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: Brain Connectivity, fMRI, Multi-echo EPIThe human olfactory network presents technical challenges for functional MRI due to its location in regions of high static susceptibility. We developed a novel multi-echo EPI (ME-EPI) protocol, optimized for olfactory regions, and compared this protocol to a conventional single-echo EPI (1E-EPI). We show that the optimized ME-EPI increases sensitivity to BOLD activation response for olfactory regions and reduces the numbers of subjects required to detect significant group effects.

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