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Abstract #0223

Investigating the endfolial pathway of the human hippocampus using ex vivo dMRI at high spatio-angular resolution

Jonathan Scharff Nielsen1 and Manisha Aggarwal1
1Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States

Synopsis

Keywords: Brain Connectivity, Tractography & Fibre Modelling, Hippocampus internal circuitry; probabilistic tractography.

The endfolial pathway is a collection of fibers within the hilus of the human hippocampus that forms part of the complex intra-hippocampal circuitry. We investigate this pathway using high-field (11.7 T), high spatio-angular resolution diffusion MRI (dMRI) of 3 intact, excised hippocampi. Using probabilistic tractography and computational unfolding of the hippocampal strata, we demonstrate a unique sensitivity of dMRI to the 3D trajectory of the intra-hippocampal fibers.

Keywords: Ex vivo high spatio-angular resolution diffusion MRI; hippocampus internal circuitry; probabilistic tractography.

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Keywords