Abstract #0231

Mapping functional connectivity of insular subdivisions using connectivity-based parcellation in adolescents with major depressive disorder

Zilin Zhou¹, Lingxiao Cao¹, Yingxue Gao¹, Ruohan Feng², Yang Li³, Weijie Bao¹, Kaili Liang¹, Lihua Zhuo², Guoping Huang³, and Xiaoqi Huang^1,4

¹Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, Chengdu, China, ²Department of Radiology, the Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang, China, Mianyang, China, ³Department of Psychiatry, the Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang, China, Mianyang, China, ⁴Psychoradiology Research Unit of the Chinese Academy of Medical Science , West China Hospital of Sichuan University, Chengdu, Sichuan, China, Chengdu, China

Synopsis

Keywords: Psychiatric Disorders, Adolescents, major depressive disorderUsing a data-driven connectivity-based parcellation technique, we identified anterior and posterior functional subdivisions of insula per hemisphere in adolescent population based on their similar functional connectivity profiles. Then, we investigated the distinct functional connectivity of each insular subregion between depressive adolescents and typical developmental controls. The significant unbalanced connectivity of insular subregions with left superior frontal gyrus (SFG) between two groups was revealed, which associated with interpersonal relation, emotional expressiveness, and cognition impairments in depressive adolescents. Our findings indicate that abnormalities in functional architectures of insular subdivisions may be the potential neuroimaging mechanism underlie the specific manifestations in adolescent depression.

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