Keywords: Brain Connectivity, Parkinson's DiseaseParkinson’s disease (PD) is not solely a disruption of motor-related networks but a consequence of impaired high-level cognitive processes, indicating that high-order information exchange in cognitively preserved patients with PD could be sensitively revealed in the high-order-functional connection (HOFC) networks. We thus attempted to characterize the topological alterations and classification performance of HOFC networks in normally cognitive patients with PD. Our findings identified the disrupted topology of functional interactions at high-level with extensive alterations of topological properties and improved differentiating ability in patients with PD prior to clinical symptoms of cognitive impairment, providing complementary insights into complex neurodegeneration in PD.
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