Abstract #0234

Functional connectivity changes of brainstem nuclei in prodromal Parkinson’s disease: A 7 Tesla resting-state study

Kavita Singh¹, Maria Guadalupe Garcia Gomar^1,2, Ambra Stefani³, Aleks Videnovic³, and Marta Bianciardi^1,4

¹Brainstem Imaging Laboratory, Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States, ²Escuela Nacional de Estudios Superiores Unidad Juriquilla, Universidad Nacional Autónoma de México, Querétaro, Mexico, ³Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States, ⁴Division of Sleep Medicine, Harvard University,, Boston, MA, United States

Synopsis

Keywords: Parkinson's Disease, fMRI (resting state), 7 Tesla MRI, REM sleep behavior disorder, prodromal PD, alpha synucleopathies, brainstem

Based on animal and human lesion studies, isolated rapid-eye-movement (REM) sleep behavior disorder (iRBD) is due to changes in arousal/motor brainstem nuclei structure and function and is recognized as the hallmark of Parkinson disease (PD). Resting-state fMRI studies in iRBD in humans mostly studied changes in nigrostriatal/nigrocortical connectivity pathway but failed to assess the brainstem circuits involved. To fill this gap, we investigated the functional connectivity of 20 brainstem nuclei relevant for iRBD using high-sensitivity and high spatial-resolution 7 Tesla resting-state fMRI, as well as a recently developed in-vivo probabilistic atlas of brainstem nuclei.

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