Abstract #0235

Dynamic co-fluctuation patterns of fMRI brain activity in temporal lobe epilepsy

Lucas E Sainburg¹, Baxter P Rogers², Catie Chang³, Dario J Englot⁴, and Victoria L Morgan²

¹Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ²Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ³Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, United States, ⁴Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, United States

Synopsis

Keywords: Brain Connectivity, Epilepsy

Temporal lobe epilepsy (TLE) presents with transient epileptic activity at rest, typically originating from the hippocampus. Here we measure dynamic functional connectivity (FC) at single functional MRI timepoints with edge timeseries to detect recurring hippocampal co-fluctuation patterns and their alterations in TLE. Three anterior hippocampus co-fluctuation patterns were detected in healthy controls. One pattern was altered in TLE, while another pattern was more frequent in TLE than controls. These changes reflect alterations in dynamic spatial patterns of FC from the epileptic focus in TLE.

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