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Abstract #0237

Disrupted vein-dominated connectivity and increased CSF involvement in ischemic stroke human brain

Jianyu Yuan1, Chaogang Tang2, Lei Zhang2, and Yi He1
1Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China, 2Department of Cerebrovascular Disease, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China

Synopsis

Keywords: Brain Connectivity, fMRI (resting state)High-resolution resting-state (rs) fMRI enables the functional mapping of vein-dominated connectivity, correlated with neuronal calcium signals. Here, we performed high-resolution rs-fMRI to examine 30 ischemic stroke patients with binocular isotropic hemianopia and 10 healthy controls. The results of seed-based and independent component analysis (ICA) demonstrated the reduced vein-dominated correlation patterns. Interestingly, ICA also found increased correlations between cerebrospinal fluid (CSF) and ischemic lesions in stroke patients, showing ultra-slow oscillation frequencies up to 0.04 Hz. Our findings suggest that ischemic lesions are associated with CSF, prompting disruption of vein-dominated connectivity.

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