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Abstract #0247

Quantifying geometrical properties of the Brain Surface in Alzheimer's Disease using 3D Tortuosity

Maria Julieta Mateos1, James J. Lah2, and Qiu Deqiang1
1Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, 2Department of Neurology, Emory University School of Medicine, Atlanta, GA, United States

Synopsis

Keywords: Radiomics, Alzheimer's DiseaseAlzheimer's disease causes significant gray matter loss, which leads to changes in the brain surface's shape. In this work, we used the local gyrification index (LGI) and the three-dimensional tortuosity (𝜏3𝐷) to characterize the cortical morphology, and to determine if the obtained values were significantly different amog the Alzheimer's diagnosis. The subset of MRI studies was obtained from ADNI database. For the data analyzed, the results show that the 𝜏3𝐷 has a positive correlation with brain volume and can potentially be a biomarker for AD.

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Keywords