Abstract #0251

Association between Post-traumatic Osteoarthritis 10+ Years after ACLR and Quantitative MRI of Knee Cartilage, Menisci, and Thigh Muscles

William Zaylor^1,2, Sameed Khan^1,2,3, Richard Lartey^1,2, Brendan L. Eck^2,3, Mei Li^1,2, Sibaji Gaj^1,2, Jeehun Kim^1,2, Carl S. Winalski^1,2,3, Faysal Altahawi^2,3, Morgan H. Jones⁴, Laura J. Huston⁵, Kevin D. Harkins⁶, Michael V. Knopp⁷, Christopher C. Kaeding⁸, Kurt P. Spindler^2,9, and Xiaojuan Li^1,2,3

¹Biomedical Engineering, Cleveland Clinic, Cleveland, OH, United States, ²Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, United States, ³Department of Diagnostic Radiology, Cleveland Clinic Imaging Institute, Cleveland, OH, United States, ⁴Department of Orthopaedic Surgery, Brigham and Women's Hospital, Boston, MA, United States, ⁵Department of Orthopaedics and Rehabilitation, Vanderbilt University, Nashville, TN, United States, ⁶Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, ⁷Department of Radiology, The Ohio State University Wright Center of Innovation in Biomedical Imaging, Columbus, OH, United States, ⁸Department of Orthopaedic Surgery, The Ohio State University, Columbus, OH, United States, ⁹Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, OH, United States

Synopsis

Keywords: Radiomics, Relaxometry

The purpose of this study was to evaluate the associations between radiomic features in knee and thigh quantitative MRI with symptomatic and radiographic post-traumatic osteoarthritis (PTOA) after anterior cruciate ligament reconstruction (ACLR). Radiomic features of knee cartilage, menisci (extracted from T₁_ρmaps), and thigh muscles (extracted from anatomic images and fat fraction maps) were extracted from patient MRI 10+ years after ACLR, and features were selected for symptomatic or radiographic PTOA associations. Symptomatic and radiographic PTOA were associated with features from the medial cartilage compartments, and menisci; features from the thigh muscles were associated with symptomatic PTOA only.

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