Abstract #0254

Comparison of radio-pathomic maps of tumor probability to 5-ALA guided surgical resection cavities in glioblastoma patients

Samuel A Bobholz¹, Allison K Lowman¹, Savannah R Duenweg², Aleksandra Winiarz², Margaret Stebbins², Fitzgerald Kyereme¹, Jennifer Connelly³, Dylan Coss⁴, Wade M Mueller⁵, Mohit Agarwal¹, Anjishnu Banerjee⁶, Max Krucoff⁵, and Peter S LaViolette^1,7

¹Radiology, Medical College of Wisconsin, Milwaukee, WI, United States, ²Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States, ³Neurology, Medical College of Wisconsin, Milwaukee, WI, United States, ⁴Pathology, Medical College of Wisconsin, Milwaukee, WI, United States, ⁵Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States, ⁶Biostatistics, Medical College of Wisconsin, Milwaukee, WI, United States, ⁷Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, United States

Synopsis

Keywords: Tumors, BrainThis study sought to compare previously published autopsy-based radio-pathomic maps of pre-surgical cellularity and tumor probability to beyond-contrast 5-ALA guided resection margins to assess concordance in identifying non-enhancing tumor between the techniques. In a series of 10 cases, radio-pathomic maps were able to identify areas of non-enhancing tumor prior to surgery that coincided with either 5-ALA guided resection margins or areas of future recurrence in 7 of 10 cases, suggesting that highlighted areas on these maps indicate active, progressive tumor.

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