Abstract #0257

Early detection of brain tumor response during local hydrogel based treatment using CEST MRI

Se Weon Park^1,2, Joseph H.C Lai¹, Xiongqi Han³, Jianpan Huang¹, Vivian W.M Leung¹, Peng Xiao¹, and Kannie W.Y Chan^1,2,4,5

¹Department of Biomedical Engineering, City University of Hong Kong, Hong Kong, Hong Kong, ²Hong Kong Centre for Cerebro-Cardiovascular Health Engineering (COCHE), Hong Kong, Hong Kong, ³SiBionics, Shenzhen, China, ⁴Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵City University of Hong Kong Shenzhen Research Institute, Shenzhen, China

Synopsis

Keywords: Tumors, TreatmentCEST MRI is a non-invasive molecular imaging approach, while APT has been applied to reveal molecular changes in brain tumors. Based on our theranostic hydrogel studies, here, we demonstrated the therapeutic effect on brain tumor with a continuous decrease in tumor size over 10 days. Importantly, the APT signal showed significant decrease on day 3 after treatment when tumor size did not have a significant change. Moreover, a strong correlation between APT signal and Ki-67 staining was shown. This could be a potential application to detect early tumor responses toward local hydrogel based treatment.

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