Abstract #0258

Differentiation of subtypes and genotypes in adult-type diffuse gliomas by APT imaging

Tongling Jiang¹, Minghao Wu², Cong Xie², Xianchang Zhang³, Yaou Liu², and Yi Zhang¹

¹Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, ²Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, ³MR Collaboration, Siemens Healthineers Ltd., Beijing, China

Synopsis

Keywords: Tumors, BrainAPT-related metric maps were applied to differentiate subtypes and genotypes of adult-type diffuse gliomas following the latest 2021 WHO guidelines. One hundred and twenty-nine patients were imaged on a 3T scanner. Regions of interest were obtained with an automatic segmentation algorithm on conventional anatomical images, which were then resampled and matched with the CEST images. The mean CEST metric values were calculated in the automatically-defined regions of interest, and the receiver operating characteristic analysis was implemented, achieving generally successful performance in identifying the IDH status and part of the subtypes.

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