Abstract #0263

Radio-pathomic maps of glioblastoma identify phenotypes of non-enhancing infiltration associated with bevacizumab treatment response

Samuel A Bobholz¹, Alisha Hoefs¹, Jordyn Hamburger¹, Allison K Lowman¹, Savannah R Duenweg², Aleksandra Winiarz², Margaret Stebbins², Fitzgerald Kyereme¹, Jennifer Connelly³, Dylan Coss⁴, Wade M Mueller⁵, Mohit Agarwal¹, Anjishnu Banerjee⁶, and Peter S LaViolette^1,7

¹Radiology, Medical College of Wisconsin, Milwaukee, WI, United States, ²Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States, ³Neurology, Medical College of Wisconsin, Milwaukee, WI, United States, ⁴Pathology, Medical College of Wisconsin, Milwaukee, WI, United States, ⁵Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States, ⁶Biostatistics, Medical College of Wisconsin, Milwaukee, WI, United States, ⁷Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, United States

Synopsis

Keywords: Tumors, TumorWe tested the hypothesis that autopsy-based radio-pathomic maps of glioblastoma pathology reveal distinct phenotypes (hypercellular, hypocellular, hybrid, and well-circumscribed fronts) that differ in patient survival and bevacizumab treatment response. Patients with tumor invasion beyond contrast showed worse survival outcomes compared to patients with well-circumscribed tumors. Additionally, patients with hypocellular components of the non-enhancing front selectively benefit from bevacizumab treatment, with an observable reduction in the hypocellular volume over the course of bevacizumab use.

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