Abstract #0264

Neurite orientation dispersion and density MR imaging: discriminating atypical high-grade glioma from primary central nervous system lymphoma

Eryuan Gao¹, Guohua Zhao¹, Huiting Zhang², Peipei Wang¹, Xiaoyue MA¹, Jie Bai¹, Xu Yan², Guang Yang³, and Jingliang Cheng¹

¹Department of Magnetic Resonance, the First Affliated Hospital of Zhengzhou University, Zhengzhou, China, ²MR Scientific Marketing, Siemens Healthcare, Shanghai, China, ³Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China

Synopsis

Keywords: Tumors, Neuro, atypical high-grade glioma, primary central nervous system lymphomaPreoperative differentiation of atypical high-grade glioma (HGG) (with no or little necrosis) and primary central nervous system lymphoma (PCNSL) may help to develop treatment plans. However, they share similar appearance in routine MR images. As a new diffusion model, neurite orientation dispersion and density imaging (NODDI) reflects the microstructure of tissue by measuring different components within it. Through quantitative analysis, we found that all parameters of NODDI performed excellent in distinguishing between atypical HGG and PCNSL.

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