Abstract #0265

Exploring neuroimaging biomarkers and their correlations to neurocognitive function in adult childhood cancer survivors

Maria Ljungberg^1,2, Oscar Jalnefjord^1,2, Isabelle Rydén³, Erik Fernström⁴, Linnea Andersson^1,2, Justin Schneiderman³, Malin Blomstrand⁴, Marie Kalm⁵, Isabella Björkman-Burtscher⁶, and Marianne Jarfelt⁴

¹Department of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, ²Department of Medical Physics and Biomedical Engineering, Sahlgrenska University Hospital, Gothenburg, Sweden, ³Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, ⁴Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, ⁵Department of Pharmacology, Institute of Neuroscience and Physiology , Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, ⁶Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Synopsis

Keywords: Tumors, Radiotherapy, DTI, MR spectroscopyCranial radiotherapy (CRT) is effective; however, survivors of childhood cancer often suffer from cognitive deficits. Two adult patient groups that received different CRT exposures as children were included, as well as healthy volunteers. The MR-examination comprised of anatomical imaging, DTI and MR spectroscopy of the hippocampus. Differences were found between the group that received highest CRT dose and the control group in hippocampal volume, tNAA/tCr-ratio of hippocampus and several DTI-measures in e.g., corpus callosum. Correlations was found between DTI-measures (MD/RD/AD) in some of the studied white matter tracts and several of the used neuropsychological tests, e.g., BVMT-R Sum and Coding.

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