Abstract #0266

Predicting IDH1 Expression using Computational Modeling of Interstitial Fluid Pressure in Glioblastoma

Jianan Zhou^1,2,3, Wentao Hu⁴, Zhengyang Zhu⁵, Xin Zhang^1,2,3, Yongming Dai⁴, and Bing Zhang^2,3,5,6,7

¹Department of Radiology，Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing,Jiangsu Province,China, China, ²Institute of Medical Imaging and Artificial Intelligence, Nanjing University, Nanjing, China, ³Medical Imaging Center, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China, ⁴MR Collaboration, Central Research Institute, United Imaging Healthcare, Shanghai, China, Shanghai, China, ⁵Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing,Jiangsu Province,China, China, ⁶Jiangsu Key Laboratory of Molecular Medicine, Nanjing, China, ⁷Institute of brain Science, Nanjing University, Nanjing, China

Synopsis

Keywords: Tumors, Contrast Agent

The immunohistochemistry features of glioblastoma have important influence on its occurrence and prognosis. Understanding the noninvasive detection of interstitial fluid pressure (IFP) and velocity (IFV) based on dynamic contrast enhanced (DCE)-MRI to explore the correlation between IFP and IFV with immunohistochemical markers of glioblastoma. The investigation demonstrates that IFP indicators have significant correlation with isocitrate dehydrogenase 1 (IDH1) expression and Ki-67 level of glioblastoma, and could help diagnose IDH1-mutation patients.

Keywords

Glioblastoma，Interstitial Fluid Pressure and Velocity，IDH1，Ki-67

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