Abstract #0270

High-resolution whole-brain multi-parameter mapping at 7 Tesla with interleaved fly-back 3D-EPI and universal pTX pulses

Rüdiger Stirnberg¹, Yannik Völzke¹, Daniel Löwen¹, Eberhard Daniel Pracht¹, Vincent Gras², Nicolas Boulant², Siya Sherif³, Difei Wang¹, Mónica Ferreira¹, Jennifer Faber^1,4, and Tony Stöcker^1,5

¹German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, ²Commissariat à l’Energie Atomique, CNRS, NeuroSpin, Baobab, Université Paris-Saclay, Gif sur Yvette, France, ³GIGA - Cyclotron Research Centre - In Vivo Imaging, University of Liège, Liège, Belgium, ⁴Department of Neurology, University Hospital Bonn, Bonn, Germany, ⁵Department of Physics and Astronomy, University of Bonn, Bonn, Germany

Synopsis

Keywords: Quantitative Imaging, High-Field MRI, MPM, QSM, 3D-EPIWe present a versatile high-resolution whole-brain multiparametric/susceptibility mapping protocol at 7T, introducing interleaved fly-back skipped-CAIPI 3D-EPI. To overcome the impeding limitations of B₁⁺ inhomogeneity, universal pTX pulses for excitation and magnetization transfer saturation are employed. Within 17 minutes scan time, 0.6mm isotropic whole-brain MT-/PD-/T1-weighted magnitude and phase images at four echo times and corresponding quantitative parameter maps are obtained. Supplementary output, like SWI and MPRAGE-like images can be generated as well. Scan efficiency is high and geometric distortions are negligible. Optionally, the interleaved fly-back acquisition allows a separate analysis of two monopolar readout images.

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