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Abstract #0273

In-Vivo T2 measurements of fetal brain in 1.5T

Suryava Bhattacharya1, Anthony Price1,2,3, Alena Uus1,3, Helena S. Sousa1, Massimo Marenzana2,3, Kathleen Colford2,3, Peter Murkin2,3, Maggie Lee2,3, Lucilio Cordero-Grande3,4, Rui Pedro Azeredo Gomes Teixeira1,3, Shaihan J. Malik1,3, and Maria Deprez1,3
1Department of Biomedical Engineering, King's College London, London, United Kingdom, 2Guy's and St Thomas Trust, London, United Kingdom, 3Centre for the Developing Brain, King's College London, London, United Kingdom, 4Biomedical Image Technologies, ETSI Telecomunicación, Universidad Politécnica de Madrid and CIBER-BBN, Madrid, Spain

Synopsis

Keywords: Quantitative Imaging, FetusFetal brains go through rapid development, resulting in significant changes in tissue observable by MRI, during gestation. This work presents a quantitative MR imaging pipeline that aims to measure T2 relaxation in fetal brains from clinically acquired single-shot TSE sequences, reconstructed using slice to volume registration (SVR). Images with different echo times (TE) were acquired using a 1.5T MR system; we explored both a simple exponential decay model and more complex simulation-based dictionary for T2 estimation. Measured T2 values are greater than estimates from neonates and developmentally important regions such as the subplate are visible with significantly longer T2s.

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Keywords