Abstract #0274
A normative cortical T1 atlas for single-subject pathology detection at 7T
Samuele Caneschi1,2,3, Tom Hilbert1,2,3, Gabriele Bonanno4,5,6, Robert Hoepner7, Roland Wiest5,8, Piotr Radojewski5,8, Bénédicte Maréchal1,2,3, Jean-Philippe Thiran2,3, Tobias Kober1,2,3, and Gian Franco Piredda1,9,10
1Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland, 2Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, 3LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 4Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Bern, Switzerland, 5Translational Imaging Center (TIC), Swiss institute for Translational and Entrepreneurial Medicine, Bern, Switzerland, 6Magnetic Resonance Methodology, Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Bern, Switzerland, 7Department of Neurology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland, 8Support Center for Advanced Neuroimaging, Institute for Diagnostic and Interventional Neuroradiology, Inselspital, University of Bern, Bern, Switzerland, 9Human Neuroscience Platform, Fondation Campus Biotech Geneva, Geneva, Switzerland, 10CIBM-AIT, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
Synopsis
Keywords: Quantitative Imaging, Data Processing, Brain cortexQuantitative MRI allows establishing normative atlases of relaxometry parameters which enable single-subject comparisons for anomaly detection. The large anatomical inter-subject variability of the brain cortex and its convoluted shape, however, complicate such comparison in this region. In this study, a method to align inter-subject brain cortices is proposed and a voxel-wise normative T1 atlas in the cortex is built from a cohort of 133 healthy subjects scanned at 7T. The atlas is used to detect and characterize T1 alterations in two multiple sclerosis patients on a single-subject basis.
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